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In asthma, peroxisomal dysfunction may impair antioxidant defenses in airway epithelium, increasing vulnerability to environmental triggers (e.g., air pollutants) (104)

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A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies