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An important study demonstrated that heme triggers tissue macrophage differentiation by inducing the transcriptional factor Spic in monocytes through a mechanism dependent on the degradation of the transcriptional repressor Bach1 (99)

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In the event of IBDs, the relevance of polyphenols has been described in previous literature, exerting their benefits in this condition by many different mechanisms including the reduction of epithelial damage, inflammation, hemorrhage, oxidative stress, gut dysbiosis, apoptosis, gland dysfunction, bloody stools, and ulcerations while promoting an increase in mucin content, number of crypts and reinforcing the integrity of the epithelial barrier [47]

This physiological process together with the renal Ca 2+ reabsorption and the bone Ca 2+ resorption maintain the Ca 2+ homeostasis

doi: 10.1038/s41591-020-01183-8 133 SmithPMHowittMRPanikovNMichaudMGalliniCABohloolyYMet al