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Rotenone results in gut dysbiosis and this is reversed by the downregulation of CPT1 Over the last decade, PD has been shown to be a multisystem disease with pathology outside the CNS, e.g., -syn has been located in the gut prior to the brain 51,52

(129), contrary to expectations, IF resulted in higher levels of anti-dsDNA antibodies, immune complex deposition, and glomerular damage in the kidneys compared to the control group

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An increase in SOD has also been shown in humans follwing both acute and long term exercise [53]

34 , e2207107 (2022)