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Levels naturally decline with age

2 Materials and methods A comprehensive narrative review was conducted through systematic searches of PubMed, Scopus, and regulatory databases (FDA, WADA) from inception through January 2026

J Biol Chem (2001) 276:3098794

The WHO recommends that once the vial of bacteriostatic water is open the preservatives will prolong its life for up to 28 days and after this period of time the vial should be discarded