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The mechanism proceeds as follows: Mitochondrial Disruption: The KLAKLAK sequence disrupts the outer mitochondrial membrane, causing cytochrome c release and depolarizing the membrane potential

We also proposed to update the MEI increase for CY 2025 based on historical data through the second quarter of 2024, and we proposed to use such data, if appropriate, to determine the final MEI percentage increase and the CY 2025 KX modifier threshold amounts in the CY 2025 PFS final rule

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