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doi: 10.1016/j.jprot.2010.02.014 12 TelezhkinVBrazierSPCayzacSMllerCTRiccardiDKempPJ

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The study of Rasmus Hansen and colleagues demonstrated that inhibitors exhibit an only weak and reversible binding affinity for KRAS (G12C), but the chemical reaction between the targeted cysteine and inhibitors is powerful and is accelerated by KRAS (G12C) as an enzyme that specifically catalyses covalent bond formation between groups with low intrinsic reactivity 125

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Role of mitochondria and mitochondria-targeted agents in non-alcoholic fatty liver disease