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TGF- pathway Ionizing radiation-induced ROS activate latent TGF-1 by oxidizing Met253 in its LAP, triggering conformational changes, suggesting the isoform specificity of ROS in TGF- activation

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GDH promotes the metabolism of glutamate and glutamine to generate ATP, which is profoundly increased in multiple human cancers

Moreover, for patients with renal and liver failure, anorexia and restriction of foods rich in protein, potassium, and phosphate contribute to decreased folate intake