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As it is not feasible to include all preclinical studies on this topic in this review, the contents of the subsequent sections are focused on representative, high-quality studies

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Site rotation protocol Rotate injection sites every week

For long-term storage (many months), they can be kept in a freezer

Frequently, brain tumor and its therapy are endocrinologically devastating for children, and the most common residua are growth failure or short stature, which may be caused by the high rate of GHD in children after cranial radiation and radiation effects on skeletal growth after spinal or whole-body radiation treatment (Schriock et al., 1991)