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Many studies demonstrated that a variety of chronic inflammatory conditions are strongly associated with cancer development, such as IBD (150) and pancreatitis (151153)

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Cells 10(10):2516 Ghallab A, Hassan R, Hofmann U et al (2022) Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

Efficient uptake of iodine, selenium, iron, and zincmicronutrients governing thyrocyte function from hormone synthesis (iodination, TPO activity) to peripheral activation (DIO-mediated T 3 generation)serves as a therapeutic target in hypothyroidism and Hashimotos thyroiditis, particularly in populations with coexisting deficiencies (Shulhai et al., 2024)

Phase I study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) administered with PD-L1 inhibitor (Atezolizumab) in advanced solid tumors