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At the same time, this transient physiological hypoxia could promote the timely repair of the exfoliated endometrial surface and prevent excessive menstrual bleeding, which is mostly meditated by hypoxia-induced high expression of vascular endothelial growth factor (VEGF) ( Figure 1 The role of hypoxia-inducible factors in endometriosis Hypoxia ( Figure 2 ) ( Figure 2 However, in a state of moderate hypoxia, which means that the oxygen content is less than 1%, many cells can still survive

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