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FIGURE 7 Since sequence alignment of CopR revealed a potential copper binding site, it was speculated that Cu binding may affect its ability to bind cop boxes

This is consistent with a previous finding that the high-intensity green BODIPY signal co-localizes with lysoTracker, a marker for LROs [8]

Reprod., 1994, doi: 10.1093/oxfordjournals.humrep.a138391

CrossRef Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic -Cells to Type 2 Diabetes Petr Jeek, Martin Jabrek, Lydie Plecit-Hlavat Antioxidants & Redox Signaling.2019

The CUL3 construct corresponded to the N-terminal domain (NTD) of CUL3, which binds the substrate receptor, and lacked the C-terminal domain, which binds RBX1