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Randomized Open-Label Phase II Study of Decitabine in Patients With Low- or Intermediate-Risk Myelodysplastic Syndromes

7 , e1016 (2018)

G., Brimer, C., and Schuetz, J

Furthermore, DNA damage can accelerate primordial follicle depletion and contribute to the decline in reproductive function by activating phosphatase and tensin homolog (PTEN)/PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathways (69)

Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division