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Description

You can imagine NAD+ as the tiny, rechargeable batteries that power everything you do, especially in your energy-hungry brain

Rotenone can freely cross the bloodbrain barrier and is a well-established mitochondrial toxin that specifically inhibits the complex I (NADHdehydrogenase) of the electron transport chain leading to ATP depletion, energy failure and mitochondrial ROS production, which in turn induces cytochrome C release and apoptotic cell death (Clayton et al., 2006