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Following the loss of the tumor suppressor gene neurofibromin and the subsequent activation of the Ras pathway, several intracellular signaling cascades are rearranged and impact on cellular processes relevant to cancer progression (e.g

doi: 10.1089/pho.2009.2547

European journal of paediatric neurology: EJPN: official journal of the European Paediatric Neurology Society2, 313-318 (1998)

The fact that the LC3/GABARAPs are conjugated to the autophagosomal membrane, which can situate them at high concentration on a 2D surface, offers one potential mechanism by which they could mimic an oligomeric state