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Conversely, blocking SLC5A12 was shown to decrease disease severity 58

doi: 10.1038/mi.2008.53 99 AndresenL

Metals and neurotoxicology

Furthermore, kynurenine is a glutaminergic receptor antagonists and quinolinic acid even blocks this receptor 28

Tissues were weighed then homogenized using Qiagens TissueLyzer in 800 l ice-cold 50:50 methanol:water solution per 50 mg tissue, with BIS-TRIS (Sigma-Aldrich) at 125 ng/ml was used as an internal control, in 2 ml microtubes containing one 3 mm Tungsten carbide bead (Qiagen), for 10 min at a frequency of 25 Hertz