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Although TAGs do not function as signaling molecules per se, the lipid intermediates generated during lipogenesis and lipolysis influence intracellular insulin signaling and participate in progression of IR

However, it exhibited low oral bioavailability (Table 1), and thus, we further modified RNK06138 to improve its pharmacokinetic profile using a shorter linker

Our findings suggest that GSH depletion induces ferroptosis, autophagy, and SIPS

This analysis suggested that the cutoff point for redox index to maximize its sensitivity and specificity was 2.0 (sensitivity: 91.1%, specificity: 42.9%) (Fig 5)

Human, animal, or adjacent evidence