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This analogy is important both for conceptualizing the uric acid crystals in the joint and for understanding the various types of gout treatment (see below), some of which attack the inflammation (pour water on the flaming matches) and some of which remove the uric acid crystals (take away the matches)

Reactive oxygen species (ROS), which are secreted into the synovial fluid by inflammatory cells as a result of the increased cytokine levels, have been identified as a significant driver of joint damage in RA patients [8]