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In severe cases, your doctor may recommend laxatives

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Pepsensyal (Acetyl sh-Tetrapeptide-1 derivative): This 99% natural-origin peptide demonstrated in a double-blind, split-face trial with 32 women aged 44-64 years: 11% reduction in crow's feet roughness, 14% reduction in relief amplitude, and 21% increase in dermal echogenicity within 28 days