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While it may be possible to generate microglia-containing COs, these spontaneous formation, self-directed protocols are not yet robust and well established in terms of cell ratio and heterogeneity between patient iPSC lines

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20,33,106 Individuals with early-onset and progressive liver disease, unexplained cholestasis, ICP, LPAC, drug-induced cholestasis, or a family history of cholestatic diseases should consider genetic testing for ABC transporter mutations

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