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In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]

Interestingly, in healthy men, low dietary Se intake (13 g/day for ~100 days) decreased serum, erythrocyte, and seminal plasma (but not sperm) Se concentrations, without influencing serum androgen, LH, and FSH concentrations, and decreased concentration and total number of sperm, increased the proportion of tailless sperm, but decreased the proportion of headless sperm (185)

This receptor-level distinction is what mechanistically separates the two, despite both falling under the broader category of growth hormone secretagogue research