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Sulfur-based nucleophiles have been employed in nucleophilic ring opening of epoxides in hindered systems [18-23], with most examples of the latter occurring at quaternary carbon atoms which are part of ring systems [18-22], and in particular in steroids [18-20]

* Correspondence: Victor Uchenna Chigozie, [email protected] ORCID: Victor Uchenna Chigozie, orcid.org/0000-0003-4139-0124 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The thioredoxin system Thioredoxins (Trx) are small disulphide-containing redox proteins that have been found in all the kingdoms of living organisms [39]

For example, while omega-3 fatty acids, folic acid, and CoQ10 reduced the risk of cardiovascular disease, selenium and vitamins C, D, and E had no effect on the risk for either cardiovascular disease or type 2 diabetes (which often coincides with cardiovascular disease)

It possesses anti-inflammatory, antioxidant, and free radical scavenging properties