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Accumulating evidence indicates that sepsis-induced neuroinflammation activates microglia, triggering a pro-inflammatory cytokine storm (TNF-, IL-1, IL-6) that exacerbates mitochondrial dysfunction and ROS burst in hippocampal neurons (Michels et al., 2015

It was found that after CDPS intervention, the autonomous activity of SD rats was improved, shortened swimming static time and the decreased number of autonomous standing activities were restored, and the protein expression of Wnt1 and -catenin in the substantia nigra was increased compared with the PD model group

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