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At concentrations exceeding 50 M, H 2 S can have detrimental effects, including mitochondrial poisoning due to the inhibition of cytochrome c oxidase (complex IV) (Cooper and Brown, 2008

VEGFR2 study remains one of the most-cited mechanistic papers on this peptide

JCI Insight 2(7):e90777 Lill R, Dutkiewicz R, Freibert SA, Heidenreich T, Mascarenhas J, Netz DJ, Paul VD, Pierik AJ, Richter N, Stmpfig M, Srinivasan V, Stehling O, Mhlenhoff U (2015) The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins

By contrast, for NTS treated with AS + RESV, tegumental disruption and disappearance of basal membrane were apparent