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Arginine-metabolism and functions in the human organism

doi: 10.1165/rcmb.2018-0335OC 78

However, the efficacy, stability, and safety of the agents, as well as whether they could disturb local or systemic energy metabolism should be considered comprehensively in future clinical uses

4,42 Ischemic rest pain usually begins distally in the toes and foot, is worse with the leg elevated (eg, at night when the patient is in bed), and is relieved with dependency (hanging the leg over the side of the bed, standing or sitting in a chair)