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57 : 185196 Pettegrew JW

The activation of the NF-B signaling pathway can also promote the activation of sterol regulatory element binding protein (SREBP), upregulating the expression of downstream enzymes involved in fatty acid synthesis (such as elongases and fatty acid synthase), inducing significant fatty acid synthesis and further promoting the polarization of macrophages towards the M1 phenotype

Genome 9, 608610

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Conclusively, these results suggest that ALC is capable to attenuate kainate-induced SE which is somewhat mediated through its lowering of oxidative stress, neuroinflammation, and pyroptosis that are related to its neuroprotective effect