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This large-scale study indicated that there was no increase in OS levels in MDD and anxiety disorders

Its established side effects in the clinical setting include dizziness, headache, restlessness, nausea, and, less commonly, serotonin syndrome when combined with other serotonergic drugs (Loane and Politis 2012)

However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

Zhang, J.-L