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Cellular Factors and Signaling The reactivation of KSHV can be initiated artificially by treating latently infected cells with certain chemicals such as 12-O-Tetradecanoyl-phorbol-13-acetate (TPA) and sodium butyrate (Miller et al., 1997)

Nevertheless, the most challenging part of LV systems is random integration into host cell genomes

Several studies have shown that TGF-1 upregulates glutaminase 1 (GLS1), enhancing the conversion of glutamine to glutamate, a critical step for collagen biosynthesis [97,98,99]