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Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

Dikoma Shungu has been pivotal

Peptides derived from insulin granule proteins are targeted by CD8+ T cells across MHC class I restrictions in humans and NOD mice

Inhibitors of this system, such as Erastin, drastically reduce intracellular GSH levelsby over 80%thereby impairing GPX4 function and triggering ferroptosis (Ayton et al., 2017)