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Replicates were run on tissue from the same donor

Intrathecal administration, while conceptually the most direct way to approach brain iron, is highly invasive and currently studied only in experimental scenariosit may be considered in extreme cases or acute CNS iron toxicosis, but it is not a routine approach due to the safety and logistical challenges

In renal cells of DKO mice(GSTT1/GSTM1-DKO), cisplatin-induced nephrotoxicity is primarily mediated through oxidative stress and ferroptosis pathways, with Fer-1 acting as a ferroptosis inhibitor and NAC as an antioxidant, effectively alleviating damage caused by these mechanisms (6062)

A combination of methods (e.g

10.1093/jn/103.10.1454 [PubMed: 4200872] [CrossRef] Oppermann JA, Muldoon E, Ranney RE (1973b)