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Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial

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As FcRn has also been implicated in active transport of IgG Fc based biologics from the airway lumen to the systemic circulation 38 , we next administered anti-NIP IgG1 WT and REW intranasally (i.n.) and measured their concentrations in plasma 24 h post-delivery (Fig