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Although most studies in patients receiving Bu based conditioning regimens show positive significant contributions of these haplotypes with Bu pharmacokinetics (PK), adverse events, or disease risk 22,23,24,25 , there are still several other studies that have reported negative findings, casting doubt on the role of the promoter SNPs

Dissemination of these clones could partly be due to carriers, where it is estimated for every VRE patient, there are 210 fold more transient carriers [101]

Dil, E., Ghaedi, M., Asfaram, A., Tayebi, L

Johnson M, Kumar P, Molina J-M, Rizzardini G, Cahn P, Bickel M, et al

Oxidative stress occurs when theres an imbalance between free radicals and antioxidants, often leading to cellular damage