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It could potentially be important in cognitive function and neurodegenerative diseases.[ref] Animal studies show that thiamine could improve cognition via modulating GSK-3B expression.[ref] In hospitalized patients with sepsis, a combination of IV thiamine, vitamin C, and hydrocortisone vastly improved the mortality rate compared to a control group.[ref] An animal study of induced myocardial infarction (heart attack) showed that benfotiamine administered before and after the heart attack had improved cardiac markers.[ref] Thiamine deficiency (mild or severe) is significantly associated with cognitive impairment and mood changes in cancer patients.[ref] A 2026 genome-wide association study paired with Mendelian randomization found that thiamine transport and activation are key in intestinal motility and IBS-C

When oxidative stress is high, glutathione levels can drop, making it harder to get deep, restorative sleep

If skin were a building, fibroblasts would be the crew that pours the foundation and patches the walls

Lao H, Zhu Y, Yang M, Wang L, Tang J, Xiong H

R01NS065013, M.J.L.)