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285 subjects with both BL and W96 ANALI score had a median increase by one point [1, (0,2)] at W96

A virtual blank was created with a buffer and reagent solution, and samples were mixed with a buffer solution and ethylenediaminetetraacetic acid

& Morrisett, R

(Some other chealators may also be effective although they are not approved for this indication.) Hemodynamic stabilization (crystalloid solutions - to replace what is lost by diarrhea & vomiting)