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Recommendation 11: Tapering of bDMARDs In patients with axSpA in sustained remission for at least 12 months and receiving treatment with bDMARDs, tapering (reducing the dose or extending the intervals) of bDMARDs is conditionally recommended

This structure reveals that several amino acids in the E2 C-terminus (the region from R659 to I690) and E1 N-terminus (Y192-N205) establish crucial interactions in the E1/E2 interface