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For the E-64d cocrystal structure, where density in the 2 F o F c maps failed to cover all of the ligands aliphatic tail moieties, the pose of the ligand that was best accommodated by the density and gave the lowest R free in refinement was selected and a feature-enhanced 2 F o F c map was calculated in PHENIX from the original reflections and the optimized model to better justify ligand placement 85

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Antioxidant and Redox Signal 2007

Endogenous kynurenines as targets for drug discovery and development

Although his bills along those lines failed, they galvanized efforts to address housing costs through state action on zoning