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Biochim Biophys Acta Gen Subj (2022) 1866:130239

Moreover, tumors from transsulfuration capable tissues downregulated this pathway, while tissues lacking transsulfuration activity generated transsulfuration deficient tumors

B12 is also required for several other processes that support nervous system function, including the conversion of homocysteine to methionine, which can damage the nervous system by generating oxidative stress