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This notion is illustrated by MASLD and MASH pathobiology [99] pointing to the investigation of coppers role as a potential avenue to uncover important sex-specific pathogenic mechanisms of MASLD initiation, and fibrotic progression [49,58,79,100-102] and the development of targeted therapies that, moving beyond symptomatic treatment, address the underlying root causes of MASLD in individual patients [86]

Tutton MG, George ML, Eccles SA, Burton S, Swift RI, Abulafi AM

J.WrightJ

Materials and Methods The authors used the Broad Institute's Connectivity Map (CMap) - a publicly available computer-based gene profiling tool

Kim D, Garza LA (2017) The negative regulator CXXC5: making WNT look a little less dishevelled