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Yet, gonadorelin stands out for its ability to kickstart the HPG axis even after a single injection, as it stimulates the release of both LH and FSH

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In vitro , low mM concentrations (e.g., 8.5 mM) reduce TEER and increase permeability across Caco-2 monolayers without compromising epithelial integrity, suggestive of a paracellular mechanism (Lindmark et al., 1995)

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