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Indeed, the concentrations of esterified phytoprostanes can be an order of magnitude higher than those of the equivalent free jasmonates and two to three orders of magnitude higher than of analogous isoprostanes in animal tissues

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The lack of this basic residue in ROXY9 might add to its poor scaffold site either through its effect on the position of the loop or on other interactions within the thioredoxin fold

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Saffrons pharmacology (boosting dopamine/serotonin) means one should use caution if combining it with other serotonergic substances (like antidepressants such as SSRIs) to avoid any risk of serotonin overload