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In a first-in-human clinical trial, intravenous ascorbate at pharmacological doses combined with radiotherapy and adjuvant chemotherapy with TMZ assured safety, as well as potential therapeutic efficacy in newly diagnosed glioblastoma patients [89]

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Silencing this gene can decrease Bcl-2 expression and increase Bax protein expression, leading to a reduced Bcl-2/Bax ratio, thereby promoting prostate cell apoptosis [38]