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B vitamin aids in red blood cell formation and reduces the risk of birth defects when taken during the first few months of pregnancy

However, when combined with HA, the drug may remain longer in the joint cavity, increasing bioavailability and therapeutic potential

C.LauneD.TrinquierS.LapradeM.et al (1998)

Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

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