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In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18, 20, 50, 87], although CNS depression may be delayed if a slow-release preparation has been ingested [12, 50]

Its versatility in detection modes is enhanced by advancements in backpressure regulator, injector, and column technology in new-generation instruments (Antonelli et al., 2022), enabling its combination with open cell detectors in MS (Le Faouder et al., 2021) and evaporative light scattering detectors (ELSD) (Lipka et al., 2019) for broader applications (Gros et al., 2021)

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Muriach M et al (2014) Diabetes and the brain: oxidative stress, inflammation, and autophagy

They hypothesized that cysteine deprivation impairs the ETC activity and Krebs cycle, leading to hyperpolarization of the IMM followed by lipid peroxidation [230]