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Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

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Ethics declarations Ethical approval and consent to participate Animals were treated according to the EU council directive 2010/63/EU and the German Law on Animal Protection with approvals for breeding and the procedures by the respective government agency (Lower Saxony State Office for Consumer Protection and Food Safety)

Emerging modalities such as electro-fields therapy 4 and focused ultrasound therapy 5 have also shown promising advancements in solid tumor therapy in clinic or pre-clinical settings

By incorporating patient-specific data, such as genetic markers and tumor microenvironment characteristics, MSN-based treatments could be customized for maximum efficacy