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Specifically, the prediction and screening of potential depression-related targets were performed using Similarity Ensemble Approach (SEA) at the Search Tool for Interactions of Chemicals (STITCH) at SwissTargetPrediction at Therapeutic Target Database (TTD) at Comparative Toxicogenomics Database (CTD) at PharmGKB at DisGeNET at and GeneCards at Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Enrichment of selected targets were performed using the online bioinformatics tool DAVID at Interestingly, the pathway enrichment analysis suggests that active herbal compounds mainly target serotonergic synapse pathway (KEGG: map04726) and dopaminergic synapse pathway (KEGG: map04728) in relation to depression

However, it also did not significantly increase levels of the protective adipokine adiponectin, an effect which was uniquely observed with the Kampo formula KBG ( The role of VE in cytokine modulation during NAFLD is complex and context-dependent

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For instance, the nickel hyperaccumulator Alyssum serpytllifolium gathered up to 72% of Ni in the vacuole (Brooks et al., 1980

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