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16 Furthermore, elevated levels of soluble UA can initiate the activation of the nucleotide-binding oligomerization domain (NOD)-, Leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 inflammasome, 17 leading to endothelial cell pyroptosis, a process modulated by cellular levels of reactive oxidative species

doi: 10.1186/S12876-023-02716-4/FIGURES/4 134 TahanGGramignoliRMarongiuFAktolgaSCetinkayaATahanVet al

Pruitt DT, Schmid AN, Kim LJ, Abe CM, Trieu JL, Choua C, Hays SA, Kilgard MP, Rennaker RL (2016) Vagus nerve stimulation delivered with motor training enhances recovery of function after traumatic brain injury

An open-label biomarker study of EMA401 was conducted in a phase II clinical trial of OIPN patients to prove the conceptual use of EMA401 in OIPN

bioRxiv preprint