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Beneficial effects of the genus aloe on wound healing, cell proliferation, and differentiation of epidermal keratinocytes

Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]

These include selenium, vitamin E, alpha lipoic acid, NAC, and SAMe

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Preservation of these spaces may facilitate regenerative cells and growth factors infiltration and more sustained exposure of biologic agents and their signaling mediators, thereby supporting tissue remodeling