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The production of oligodendrocyte progenitor cells continues in adulthood, where they are generated from neural progenitor cells

55 In addition, hypothyroidism may lead to 3) decreased cardiac output 3,54 as a consequence of systolic and diastolic dysfunction and decreased red blood cell production and 4) intrarenal vasoconstriction resulting from reduced synthesis and activity of renal vasodilators (i.e., nitric oxide, adrenomedullin), 3,55,63 thereby reducing renal perfusion