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The genetic factors of the airway epithelium associated with the pathology of asthma

Castro-Marrero J, Cordero MD, Sez-Francas N, et al

If you just keep pouring more and more fuel (NAD+) into the car (your body), it may initially seem like youre making the engine run better, but if you don't pay attention to the oil and spark plugs (other necessary systems), the car might start having problems

Glutathione, in its active form, contributes to strengthening the immune system

Based on these findings, it was recognized for the first time that impairment of antioxidant defenses (vitamin E-deficiency) and enhanced levels of PUFAs (substrates for LPO) did not just amplify the injury mechanism but switched cell death signaling typically centered around mitochondrial dysfunction (in mice on normal diets) to one dominated by acute LPO [70]