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Enhancer of Zeste homolog 2 inhibition stimulates bone formation and mitigates bone loss caused by ovariectomy in skeletally mature mice

161 Upon CCCP-induced mitochondrial depolarization or inhibition of mitochondrial respiration induced by oligomycin and antimycin (OA), and in the presence of Parkin, OMM rupture exposes the PHB1/2 heterodimer, enabling its interaction with LC3-II through an LIR domain of PHB2

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The second one suggests direct scavenging of reactive oxygen species, including hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and hydroxyl radicals (OH)