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As a result, the combination of erastin and JMF4073 both at sub-micromolar concentration acts synergistically to cause lethality in these blast-crisis CML cells

Introduction With the coming of the modern society, chronic sleep loss or sleep deprivation (CSD) has gradually become a prevalent and severe public health problem that affected millions of people worldwide (1, 2)

Deficiency in CSE promotes neurodegeneration in Huntingtons disease [18], whereas deficiency in ethylmalonic encephalopathy 1 (ETHE1 or persulfide dioxygenase, PDO), a H 2 S catabolizing enzyme, is a cause of ethylmalonic encephalopathy, which is characterized by abnormally high H 2 S levels in tissues and blood [19]

It can be used in the " cotton compress " method by placing it on a cotton ball and leaving it on the dark areas for several minutes